Morning Rounds · Rheumatology Mixed High-Yield Round Antibody Disease Key Point Anti-dsDNA SLE (specific) Titres track disease activity Anti-Sm SLE (most specific) Does not track activity Anti-histone Drug-induced lupus Anti-dsDNA absent in DIL Anti-SSA (Ro)… 

Morning Rounds · Myopathies, Sjogren's & Scleroderma Limited SSc (lcSSc) Diffuse SSc (dcSSc) Key Associations Antibody: Anti-centromere (ACA) Antibody: Anti-Scl-70 (topoisomerase I) ACA: PAH, CREST, late ILD Skin: Distal to elbows/knees Skin: Trunk, face, proximal… 

Morning Rounds · Vasculitides Large Medium Small vessel size Takayasu Arteritis Aorta & branches; <40 yrs Giant Cell Arteritis Temporal a.; >50 yrs; PMR Polyarteritis Nodosa Spares lung; HBV assoc. Kawasaki Disease Children; coronary aneurysm… 

Morning Rounds · Crystal Arthropathies Stage 1 Asymptomatic Hyperuricaemia no crystals yet Stage 2 Acute Gout Acute MSU crystal synovitis; MTP1 Stage 3 Intercritical Asymptomatic intervals; ULT target Stage 4 Chronic Tophaceous Tophi; chronic joint… 

Morning Rounds · Seronegative Spondyloarthropathies HLA-B27 MHC Class I Ankylosing Spondylitis 90% positive Reactive Arthritis 60–80% positive Psoriatic Arthritis axial: 50–70% IBD-SpA 25–75% (axial) Acute Ant. Uveitis 50% of cases B27+ nr-axSpA (no X-ray sacroiliitis)… 

Morning Rounds · SLE & Antiphospholipid Syndrome Homogeneous Speckled Nucleolar anti-dsDNA / anti-histone anti-Sm / anti-SSA / anti-SSB anti-Scl-70 / anti-RNA pol III ANA immunofluorescence patterns. Homogeneous: diffuse nuclear staining — anti-dsDNA (SLE-specific) and anti-histone… 

Morning Rounds · Rheumatology Series RheumatologyA Guide to the Morning Rounds Series Seven high-yield rounds · 35 clinical cases · NEET-PG and UPSC CMS · +4 / −1 scoring Rheumatology is examined with a particular…